User Tools

Site Tools


lecture_notes:05-01-2015

Differences

This shows you the differences between two versions of the page.

Link to this comparison view

Both sides previous revision Previous revision
lecture_notes:05-01-2015 [2015/05/01 13:22]
nsaremi
lecture_notes:05-01-2015 [2015/05/01 13:25] (current)
nsaremi
Line 1: Line 1:
 ===== BME 235 notes 5/1/2015 ===== ===== BME 235 notes 5/1/2015 =====
  
-Can learn species demographic info from a single genome +Can learn species demographic info from a single genome 
-Not sequencing 1 genome but 2 (for a diploid organism), so can compare genomes to each other+ 
 +Not sequencing 1 genome but 2 (for a diploid organism), so can compare genomes to each other
  - Each is composed of a segment of the genome of an individual from previous generations  - Each is composed of a segment of the genome of an individual from previous generations
  - Looking further and further back you are sampling 1000s of individuals  - Looking further and further back you are sampling 1000s of individuals
-Amount of heterozygosity is directly proportional ...+Amount of heterozygosity is directly proportional ...
  
 ==== Wright-Fischer model of reproduction ==== ==== Wright-Fischer model of reproduction ====
Line 16: Line 17:
  - Changes till it reaches fixation (non-segregating) or extinction  - Changes till it reaches fixation (non-segregating) or extinction
  - More generations reduce genetic variation in a population  - More generations reduce genetic variation in a population
- + rate it goes down is inversely proportional to population size (N) +        - Rate it goes down is inversely proportional to population size (N) 
- - lose variation faster with small N +                - lose variation faster with small N 
- - lose variation slower with large N+                - lose variation slower with large N
  - Markov chain with absorbing boundary (math model)  - Markov chain with absorbing boundary (math model)
  - pi(p) = p : the probability an allele with frequency p will go to fixation  - pi(p) = p : the probability an allele with frequency p will go to fixation
lecture_notes/05-01-2015.1430511765.txt.gz · Last modified: 2015/05/01 13:22 by nsaremi