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lecture_notes:05-01-2015 [2015/05/01 20:22] nsaremi |
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===== BME 235 notes 5/1/2015 ===== | ===== BME 235 notes 5/1/2015 ===== | ||
- | + Can learn species demographic info from a single genome | + | Can learn species demographic info from a single genome |
- | + Not sequencing 1 genome but 2 (for a diploid organism), so can compare genomes to each other | + | |
+ | Not sequencing 1 genome but 2 (for a diploid organism), so can compare genomes to each other | ||
- Each is composed of a segment of the genome of an individual from previous generations | - Each is composed of a segment of the genome of an individual from previous generations | ||
- Looking further and further back you are sampling 1000s of individuals | - Looking further and further back you are sampling 1000s of individuals | ||
- | + Amount of heterozygosity is directly proportional ... | + | Amount of heterozygosity is directly proportional ... |
==== Wright-Fischer model of reproduction ==== | ==== Wright-Fischer model of reproduction ==== | ||
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- Changes till it reaches fixation (non-segregating) or extinction | - Changes till it reaches fixation (non-segregating) or extinction | ||
- More generations reduce genetic variation in a population | - More generations reduce genetic variation in a population | ||
- | + rate it goes down is inversely proportional to population size (N) | + | - Rate it goes down is inversely proportional to population size (N) |
- | - lose variation faster with small N | + | - lose variation faster with small N |
- | - lose variation slower with large N | + | - lose variation slower with large N |
- Markov chain with absorbing boundary (math model) | - Markov chain with absorbing boundary (math model) | ||
- pi(p) = p : the probability an allele with frequency p will go to fixation | - pi(p) = p : the probability an allele with frequency p will go to fixation |