lecture_notes:05-01-2015
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| ===== BME 235 notes 5/1/2015 ===== | ===== BME 235 notes 5/1/2015 ===== | ||
| - | + Can learn species demographic info from a single genome | + | Can learn species demographic info from a single genome |
| - | + Not sequencing 1 genome but 2 (for a diploid organism), so can compare genomes to each other | + | |
| + | Not sequencing 1 genome but 2 (for a diploid organism), so can compare genomes to each other | ||
| - Each is composed of a segment of the genome of an individual from previous generations | - Each is composed of a segment of the genome of an individual from previous generations | ||
| - Looking further and further back you are sampling 1000s of individuals | - Looking further and further back you are sampling 1000s of individuals | ||
| - | + Amount of heterozygosity is directly proportional ... | + | Amount of heterozygosity is directly proportional ... |
| ==== Wright-Fischer model of reproduction ==== | ==== Wright-Fischer model of reproduction ==== | ||
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| - Changes till it reaches fixation (non-segregating) or extinction | - Changes till it reaches fixation (non-segregating) or extinction | ||
| - More generations reduce genetic variation in a population | - More generations reduce genetic variation in a population | ||
| - | + rate it goes down is inversely proportional to population size (N) | + | - Rate it goes down is inversely proportional to population size (N) |
| - | - lose variation faster with small N | + | - lose variation faster with small N |
| - | - lose variation slower with large N | + | - lose variation slower with large N |
| - Markov chain with absorbing boundary (math model) | - Markov chain with absorbing boundary (math model) | ||
| - pi(p) = p : the probability an allele with frequency p will go to fixation | - pi(p) = p : the probability an allele with frequency p will go to fixation | ||
lecture_notes/05-01-2015.txt · Last modified: 2015/05/01 20:25 by nsaremi
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