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=== NEWBLER a.k.a. GS De Novo Assembler Software === Newbler is a proprietary assembler provided by 454 Roche. It works in flow-space to reduce the impact of its most common sequencing error (uncertainty about the length of homopolymers).\\ It claims it can assemble a 3GB genome in one day and can use paired-end information to construct scaffolds from contigs. Currently the paired-end data must have at least 50 bases in each end, so only 454 paired-end libraries are accepted---it would be good if they relaxed that constraint so that their data could be mixed with data from other platforms. Roche 454 info about [[http://454.com/products-solutions/analysis-tools/gs-de-novo-assembler.asp|Newbler]] Wiki [[http://en.wikipedia.org/wiki/Newbler|article]].
