Table of Contents

SHARCGS

Overview

SHARCGS[1] stands for SHort read Assembler based on Robust Contig extension for Genome Sequencing.

SHARCGS is a de novo DNA assembly program that uses 25-40mers and deep sequence coverage to assemble genomes. It was used for de novo sequencing from Solexa sequencing data of Helicobacter acinonychis[2].

Website

http://sharcgs.molgen.mpg.de/

Source and Documentation

http://sharcgs.molgen.mpg.de/download.shtml

References

1. a Juliane C. Dohm, Claudio Lottaz, Tatiana Borodina, and Heinz Himmelbauer. SHARCGS, a fast and highly accurate short-read assembly algorithm for de novo genomic sequencing. Genome Res. November 2007 17: 1697-1706; Published in Advance October 1, 2007, doi:10.1101/gr.6435207.
2. a Juliane C. Dohm, Claudio Lottaz, Tatiana Borodina, and Heinz Himmelbauer. Substantial biases in ultra-short read data sets from high-throughput DNA sequencing. Nucleic Acids Research Advance Access published on July 26, 2008, doi:10.1093/nar/gkn425